Agaricus Blazei (Hime-Matsutake)
A Premium Medicinal Fungus
Agaricus Blazei
Agaricus Blazei, also known as Hime-Matsutake, is highly regarded for its immune-enhancing proberties and ability to support metabolic health. Originally discovered in Brazil and later cultivated in Japan, this mushrom is now used in furctional foods and suplements for its potential to reaulate blood sugar, reduce inflammation, and promote cardiovascular wellness. At Herbal Treasure, we cultivate Agaricus Blazei using greenhouse cultivation on hardwood substrotes, ensuring stable and high-quality production with optimal bioactivity.
Benefits and Advantages
Immune System Support
Activates immune cells, enhancing the body’s ability to fight infections.
Blood Sugar Regulation
Improves insulin sensitivity and helps maintain healthy blood glucose levels.
Anti-Inflammatory and Antioxidant Effects
Reduces inflammation and protects cells from oxidative stress.
Cardiovascular Health
Lowers cholesterol levels and promotes healthy blood circulation.
Liver Health and Detoxification
Supports liver function by promoting detoxification and reducing toxin buildup.
Anti-Fatigue and Vitality Support
Increases energy levels and aids recovery from physical stress or illness.
Scientific Harvesting And Rigorous Quality Control
Harvest Timing Control
Agaricus Blazei is hand-harvested at peak maturity, ensuring the highest levels of active compounds.
Processing and Storage
After harvesting, the mushroom undergoes low-temperature drying (40-50°C) to preserve its bioactive compounds. We also apply low-temperature sterilization without irradiation to maintain the product’s natural integrity. Powder customization options range from 80 to 1000 mesh to meet various customer needs.
Strict Quality Inspection and Certifications
Each batch undergoes rigorous testing for heavy metals, pesticide residues, and microbial content, ensuring compliance with cGMP, FSSC, EU & US Organic standards.
Advanced Extraction Process of Agaricus Blazei Mushroom Extracts
At Herbal Treasure, we utilize patented jet stream cell-wall breaking technology and advanced concentration techniques to enhance the potency of Agaricus Blazei extracts. Our low-temperature and normal-pressure extraction preserves the bioactivity of essential compounds throughout the process.
Standardized Production and Scientific Management
At Herbal Treasure, we cultivate Agaricus Blazei in greenhouses using carefully selected premium strains and hardwood substrates to replicate its natural environment. Our scientific management system ensures consistent quality and bioactivity across every batch. Our professional cultivation team provides 24/7 monitoring of environmental factors such as temperature, humidity, and airflow. This precise control promotes the accumulation of key bioactive compounds, including beta-glucans, polysaccharides, and ergosterol, enhancing the mushroom’s therapeutic potential.
What Makes Our Process Unique?
Choose Herbal Treasure’s Agaricus Blazei extracts to provide your customers with premium quality products, supported by cutting-edge cultivation techniques, advanced extraction processes, and rigorous quality control.
Scientific Research on Agaricus blazei Murill
Agaricus blazei (also known as Agaricus subrufescens) is a medicinal mushroom celebrated for its potent immunomodulatory, anticancer, and antimicrobial properties.
1. Immune System Activation
An integrative review (2011) of 14 preclinical studies (in vitro and in vivo) concluded that β-glucans from A. blazei enhance both innate and adaptive immunity—boosting cytokine production and complement system activation clinicaltrials.gov+15pubmed.ncbi.nlm.nih.gov+15onlinelibrary.wiley.com+15.
In a phase I clinical study involving multiple myeloma patients undergoing stem cell transplantation, A. blazei intake was well-tolerated with no adverse lab effects after six months .
2. Antitumor Effects & Mechanisms
Animal models administered water extract (Andosan™, primarily A. blazei) showed significantly reduced tumor formation: a 60% lower intestinal tumor load in A/J Min/+ mouse model compared to controls, along with increased cancer cell apoptosis journals.plos.org.
A 2020 review in Nutrients highlights A. blazei’s antitumor activity via β-glucan–mediated apoptosis, tumor angiogenesis inhibition, and immune activation clinicaltrials.gov+15mdpi.com+15onlinelibrary.wiley.com+15.
3. Antimicrobial & Quorum‑Sensing Inhibition
In vitro studies show that hot-water extract of A. blazei inhibits Pseudomonas aeruginosa‘s pyocyanin production, reduces flagella and twitching motility—suggesting potential to suppress biofilm formation and virulence mdpi.com.
Additional integrative reviews highlight broad antimicrobial activity, although human data remain limited .
4. Safety & Additional Benefits
Generally well-tolerated; animal and early human studies report hepatoprotective effects, improved liver enzymes in hepatitis patients, and no significant toxicity webmd.com+11en.wikipedia.org+11clinicaltrials.gov+11.
Allergic reactions may occur rarely, but overall safety is supported across studies; further randomized clinical trials are recommended
Summary Table
| Benefit | Evidence & Mechanism |
|---|---|
| Immune Enhancement | ↑ Cytokines, complement activation, T/NK-cell function (preclinical + phase I data) |
| Cancer Support | ↓ Tumor burden, triggers apoptosis, anti-angiogenic, combined immune activation |
| Antimicrobial Potential | Inhibits virulence factors (e.g. pyocyanin), disrupts biofilm formation |
| Safety Profile | No major toxicity; potential hepatoprotection; rare allergies |
References for Direct Insertion
Lima et al., “Properties affecting the immune system: integrative review of A. blazei” (J Med Food., 2011) ffhdj.com+2mdpi.com+2mdpi.com+2mdpi.com+15pubmed.ncbi.nlm.nih.gov+15liebertpub.com+15
Clinical A. blazei administration in multiple myeloma patients under HSCT; safe at 6 months
Andosan™ water extract showed 60% reduction in intestinal tumors in A/J Min/+ mice (PLOS One, 2016) journals.plos.org
Hetland et al., “Antitumor, Anti‑inflammatory and Antiallergic Effects of A. blazei” (Nutrients, 2020) sciencedirect.com+4mdpi.com+4pubmed.ncbi.nlm.nih.gov+4
In vitro biofilm/virulence study: A. blazei reduces pyocyanin, motility in P. aeruginosa clinicaltrials.gov+15mdpi.com+15sciencedirect.com+15
Review of antimicrobial effectiveness; need for more research
Hepatoprotective effects and safety in hepatitis patients (A. subrufescens) es.wikipedia.org+2en.wikipedia.org+2fr.wikipedia.org+2
